Review



nicd fragment  (Addgene inc)


Bioz Verified Symbol Addgene inc is a verified supplier  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 92
      Buy from Supplier

    Structured Review

    Addgene inc nicd fragment
    Nicd Fragment, supplied by Addgene inc, used in various techniques. Bioz Stars score: 92/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nicd fragment/product/Addgene inc
    Average 92 stars, based on 9 article reviews
    nicd fragment - by Bioz Stars, 2026-03
    92/100 stars

    Images



    Similar Products

    nicd fragment  (Addgene inc)
    92
    Addgene inc nicd fragment
    Nicd Fragment, supplied by Addgene inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nicd fragment/product/Addgene inc
    Average 92 stars, based on 1 article reviews
    nicd fragment - by Bioz Stars, 2026-03
    92/100 stars
    		  Buy from Supplier
    teto-fuw-nicd fragment  (Addgene inc)
    90
    Addgene inc teto-fuw-nicd fragment
    Loss of p 53 enhances the tumor-initiating potential of MM cells. (A) Growth curves of p 53-wt (Scr) and p 53-KO MM.1S, MM.1R, MOLP8, NCI-H929, and KMS11 cells (n = 3). (B) Primary (1°) and secondary (2°) colony formation of p 53-wt (Scr) and p 53-KO MM.1S, MOLP8, and NCI-H929 cells (n = 5). (C) Colony formation of p 53-wt (Scr) and p 53-KO MM.1R cells (n = 3). (D) Colony formation of p 53-null KMS11 (Ctrl) and KMS11 p <t>53-overexpression</t> cells (n = 3). (E) Frequency of CD138 neg and ALDH + cells within Scr and p 53-KO MM.1S, MM.1R, and MOLP8 cell lines by flow cytometry (n = 6).
    Teto Fuw Nicd Fragment, supplied by Addgene inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/teto-fuw-nicd fragment/product/Addgene inc
    Average 90 stars, based on 1 article reviews
    teto-fuw-nicd fragment - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier
    nicd cdna fragment (5456 to 7819 nucleotides; nm_001105721(1747-2531aa)  (Genechem)
    90
    Genechem nicd cdna fragment (5456 to 7819 nucleotides; nm_001105721(1747-2531aa)
    Regulation of Notch1 signaling significantly alters cell proliferation in normal adult rat brain. Immunostaining shows the increasing number of DCX+ cells on day 3 following TBI in <t>NICD-Ad</t> group, compared with sham-TBI ( A–D ) and NC-TBI ( E–H ) groups.
    Nicd Cdna Fragment (5456 To 7819 Nucleotides; Nm 001105721(1747 2531aa), supplied by Genechem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nicd cdna fragment (5456 to 7819 nucleotides; nm_001105721(1747-2531aa)/product/Genechem
    Average 90 stars, based on 1 article reviews
    nicd cdna fragment (5456 to 7819 nucleotides; nm_001105721(1747-2531aa) - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Loss of p 53 enhances the tumor-initiating potential of MM cells. (A) Growth curves of p 53-wt (Scr) and p 53-KO MM.1S, MM.1R, MOLP8, NCI-H929, and KMS11 cells (n = 3). (B) Primary (1°) and secondary (2°) colony formation of p 53-wt (Scr) and p 53-KO MM.1S, MOLP8, and NCI-H929 cells (n = 5). (C) Colony formation of p 53-wt (Scr) and p 53-KO MM.1R cells (n = 3). (D) Colony formation of p 53-null KMS11 (Ctrl) and KMS11 p 53-overexpression cells (n = 3). (E) Frequency of CD138 neg and ALDH + cells within Scr and p 53-KO MM.1S, MM.1R, and MOLP8 cell lines by flow cytometry (n = 6).

    Journal: Blood Advances

    Article Title: Loss of p 53 enhances the tumor-initiating potential and drug resistance of clonogenic multiple myeloma cells

    doi: 10.1182/bloodadvances.2022009387

    Figure Lengend Snippet: Loss of p 53 enhances the tumor-initiating potential of MM cells. (A) Growth curves of p 53-wt (Scr) and p 53-KO MM.1S, MM.1R, MOLP8, NCI-H929, and KMS11 cells (n = 3). (B) Primary (1°) and secondary (2°) colony formation of p 53-wt (Scr) and p 53-KO MM.1S, MOLP8, and NCI-H929 cells (n = 5). (C) Colony formation of p 53-wt (Scr) and p 53-KO MM.1R cells (n = 3). (D) Colony formation of p 53-null KMS11 (Ctrl) and KMS11 p 53-overexpression cells (n = 3). (E) Frequency of CD138 neg and ALDH + cells within Scr and p 53-KO MM.1S, MM.1R, and MOLP8 cell lines by flow cytometry (n = 6).

    Article Snippet: For Notch intracellular domain (NICD) overexpression, the NICD fragment (from TetO-FUW-NICD; Addgene) was cloned into the pINDUCER21 (Addgene) lentiviral vector, then transfected into MM.1S p 53-KO cells.

    Techniques: Over Expression, Flow Cytometry

    Notch1-Hes1 signaling is required for increased clonogenic growth and drug resistance of p 53-KO MM TICs. (A) Colony formation of ID1-KD, ID2-KD, and nontargeting scramble (Ctrl)-treated p 53-wt (Scr) and p 53-KO MM.1S cells. (B) Western blot analysis of NOTCH1 and HES1 expression in p 53-wt (Scr) and p 53-KO MM.1S cells after treatment with a GSI. (C) Colony formation of HES1-KD and nontargeting scramble (Ctrl)-treated p 53-wt (Scr) and p 53-KO MM.1S cells (n = 4). (D) Colony formation of GSI-treated p 53-wt (Scr) and p 53-KO MM.1S, MM.1R, and MOLP8 cells (n = 4). (E) Western blot analysis of HES1 expression after doxycycline-induced Notch1 intracellular domain overexpression in p 53-KO MM.1S cells. (F) Colony formation of Notch1 intracellular domain overexpressing p 53-KO MM.1S cells after GSI treatment (n = 6). (G) Colony formation of GSI-treated clinical MM non-del17p samples (n = 6) and del17p samples (n = 3). (H) Colony formation of p 53-KO MM.1S cells after treatment with GSI (2.5 nM) and melphalan (Mel, 1 uM) or GSI and bortezomib (BTZ, 1.5 nM) (n = 5). (I) Melphalan IC 50 values of GSI-treated p 53-wt (Scr) and p 53-KO MM.1S cells (n = 3).

    Journal: Blood Advances

    Article Title: Loss of p 53 enhances the tumor-initiating potential and drug resistance of clonogenic multiple myeloma cells

    doi: 10.1182/bloodadvances.2022009387

    Figure Lengend Snippet: Notch1-Hes1 signaling is required for increased clonogenic growth and drug resistance of p 53-KO MM TICs. (A) Colony formation of ID1-KD, ID2-KD, and nontargeting scramble (Ctrl)-treated p 53-wt (Scr) and p 53-KO MM.1S cells. (B) Western blot analysis of NOTCH1 and HES1 expression in p 53-wt (Scr) and p 53-KO MM.1S cells after treatment with a GSI. (C) Colony formation of HES1-KD and nontargeting scramble (Ctrl)-treated p 53-wt (Scr) and p 53-KO MM.1S cells (n = 4). (D) Colony formation of GSI-treated p 53-wt (Scr) and p 53-KO MM.1S, MM.1R, and MOLP8 cells (n = 4). (E) Western blot analysis of HES1 expression after doxycycline-induced Notch1 intracellular domain overexpression in p 53-KO MM.1S cells. (F) Colony formation of Notch1 intracellular domain overexpressing p 53-KO MM.1S cells after GSI treatment (n = 6). (G) Colony formation of GSI-treated clinical MM non-del17p samples (n = 6) and del17p samples (n = 3). (H) Colony formation of p 53-KO MM.1S cells after treatment with GSI (2.5 nM) and melphalan (Mel, 1 uM) or GSI and bortezomib (BTZ, 1.5 nM) (n = 5). (I) Melphalan IC 50 values of GSI-treated p 53-wt (Scr) and p 53-KO MM.1S cells (n = 3).

    Article Snippet: For Notch intracellular domain (NICD) overexpression, the NICD fragment (from TetO-FUW-NICD; Addgene) was cloned into the pINDUCER21 (Addgene) lentiviral vector, then transfected into MM.1S p 53-KO cells.

    Techniques: Western Blot, Expressing, Over Expression

    Regulation of Notch1 signaling significantly alters cell proliferation in normal adult rat brain. Immunostaining shows the increasing number of DCX+ cells on day 3 following TBI in NICD-Ad group, compared with sham-TBI ( A–D ) and NC-TBI ( E–H ) groups.

    Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

    Article Title: Notch1 Signaling Activation Contributes to Adult Hippocampal Neurogenesis Following Traumatic Brain Injury

    doi: 10.12659/MSM.907160

    Figure Lengend Snippet: Regulation of Notch1 signaling significantly alters cell proliferation in normal adult rat brain. Immunostaining shows the increasing number of DCX+ cells on day 3 following TBI in NICD-Ad group, compared with sham-TBI ( A–D ) and NC-TBI ( E–H ) groups.

    Article Snippet: We obtained the NICD cDNA fragment (5456 to 7819 nucleotides; NM_001105721(1747-2531aa)) from the cDNA library of Genechem (Shanghai, China).

    Techniques: Immunostaining

    The alteration of spatial learning and memory in model rats after TBI. ( A ) The cognitive function of the experimental rats decreased significantly after injury. Compared to other groups, the NICD-Ad group recovered more quickly and the escape latency time significantly decreased (P<0.05). ( B ) The diagram represents the memory function through the time that the rats stayed in the target quarter during the probe trial. The results revealed the sham-Ad-TBI group in the target quarter was significantly higher than sham group and NICD-Ad group on day 7 after brain injury and the NICD-Ad group recovered on day 14 after brain injury. ( C ) The diagram also represents the memory function through the time spent searching for the platform in the target quarter. On day 1 after brain injury, the NICD-Ad group had the longest time spent searching in the target quarter. The rats treated with NICD-Ad had the shortest time needed to find the platform on day 3 after brain injury compared to the sham-Ad group rats (P<0.05).

    Journal: Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

    Article Title: Notch1 Signaling Activation Contributes to Adult Hippocampal Neurogenesis Following Traumatic Brain Injury

    doi: 10.12659/MSM.907160

    Figure Lengend Snippet: The alteration of spatial learning and memory in model rats after TBI. ( A ) The cognitive function of the experimental rats decreased significantly after injury. Compared to other groups, the NICD-Ad group recovered more quickly and the escape latency time significantly decreased (P<0.05). ( B ) The diagram represents the memory function through the time that the rats stayed in the target quarter during the probe trial. The results revealed the sham-Ad-TBI group in the target quarter was significantly higher than sham group and NICD-Ad group on day 7 after brain injury and the NICD-Ad group recovered on day 14 after brain injury. ( C ) The diagram also represents the memory function through the time spent searching for the platform in the target quarter. On day 1 after brain injury, the NICD-Ad group had the longest time spent searching in the target quarter. The rats treated with NICD-Ad had the shortest time needed to find the platform on day 3 after brain injury compared to the sham-Ad group rats (P<0.05).

    Article Snippet: We obtained the NICD cDNA fragment (5456 to 7819 nucleotides; NM_001105721(1747-2531aa)) from the cDNA library of Genechem (Shanghai, China).

    Techniques: